Posted in Other 30+ days ago.
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Type: Full Time
Location: Los Angeles, California
Our laboratory focuses on understanding the molecular basis of gynecologic epithelial cancer formation, progression and treatment. In particular, we are investigating the identity of epithelial ovarian cancer stem cells and molecular pathways in these cells that could be targeted therapeutically. We are also interested in the role of genetic changes in the stroma and epithelium in endometriosis and endometrial cancer progression.
In collaboration with Principal Investigator, the candidate will be expected to perform research projects (molecular, biochemical and cellular) related to understanding the molecular, immunologic and genetic events involved in the formation and progression of gynecologic diseases. Knowledge gained from this research is then used to design and test strategies for cancer treatment and will move to clinical trials. This work requires experience in cell biology, molecular biology, and involves the use of human samples and animal models. Responsibilities will include: preparation of data management forms per protocol, tissue culture work, preparation of RNA, DNA, protein and viruses, PCR, immunohistochemistry, overseeing laboratory and equipment maintenance, ordering materials and preparation of data and manuscripts for publication.
Experience in molecular, biochemical and cellular research.
Ability to perform euthanasia on animals for research purposes.
Experience isolating tissues and doing tissue culture work.
Ability to perform biochemical techniques as well as molecular biology techniques
Interpersonal skills to effectively interact with faculty, staff, and students.
Ability to work independently and to take direction.
Ability to maintain accurate inventory of supplies and laboratory instruments.
Ability to make innovative contributions pertaining to laboratory procedures.
Ability to read abstracts or scientific articles pertaining to prosecution of broad research problems.
Ability to use lab equipment including PCR machine, centrifuges, etc.
Ability to analyze research findings and prepare clear, concise and accurate technical/statistical reports.
Ability to work standing for at least 90% of the working day.
Ability to keep records of specimen.
Working knowledge of conducting literature search.
Experience with tissue culture.
Experience with RT and real time PCR.
Skill in troubleshooting and making minor repairs of laboratory instruments/equipment.
Experience performing data entry using a PC and Mac.
Ability to prepare samples for analysis using standard methods.
Skill in writing legible, concise and grammatically correct documentation in Standard English.
Ability to assure that consent forms are properly signed, dated, and complete
Skill in processing specimens according to protocol guidelines.
Ability to complete data management forms both electronically and handwritten.
Skill in implementing software program for management of biorepository.
Ability to handle primary cells, stain them with antibodies and prepare them for FACS sorting
Previous lab experience (2 - 3 years).
Experience with molecular biology.
Ability to review operating room schedule and identify cases for tissue collection studies.