Bristol-Myers Squibb is a global Biopharma company committed to a single mission: to discover, develop, and deliver innovative medicines focused on helping millions of patients around the world in disease areas such as oncology, cardiovascular, immunoscience and fibrosis.
Join us and make a difference. We hire the best people and provide them with a work environment that places a premium on diversity, integrity, collaboration and personal development. Through a culture of inclusion, we create a better, more productive work environment. We believe that the diverse experiences and perspectives of all our employees help to drive innovation and transformative business results.
The Scientist II in Investigative Toxicology serves as an integral member of the team that supports investigative toxicology studies, in both in vitro and in vivo. This scientist will be responsible for technical activities related to molecular/cellular toxicology with emphasis on identifying mechanisms of toxicity, stem cell culture/differentiation, and skills in reporting results to NCD and Project teams as appropriate. The Scientist II is also responsible for assisting the Nonclinical Development management team in establishing and achieving long-term strategic goals and tactical objectives of the Investigative Toxicology group.
Responsibilities will include, but are not limited to, the following:
Design and conduct in vitro and molecular toxicology experiments focused on identification of mechanistic basis of toxicity including the following capacities.
Characterization of biomarker, protein and/or mRNA on investigative studies using -omic technologies.
Tissue culture systems such as conventional cell culture, co-culture models, organ culture systems, and utilization of stem cells and stem cell derived tissues
Evaluation of data using appropriate software, and interpretation/integration of results from multiple molecular endpoints to generate reports with a focus on toxicological relevance
Work collaboratively to integrate data from molecular endpoints with traditional toxicity endpoints
Manage and conduct in-house and outsourced in vivo and in vitro toxicology studies
Contribute to identification of safety risk based on projected mechanism of pharmaceutical action, literature knowledge on pathways and/or toxicological profile of competitor drugs to enable more effective investigative toxicology studies.
Facilitate collaboration with academic centers and toxicology consultants as necessary to complete investigative studies.
Maintain molecular toxicology expertise through organizational associations, literature review, continuing education, and publications.
Establish and maintain working relationship with key opinion leaders in the toxicology community, academicians, and key Celgene staff
Support Investigative Toxicology by
Addressing development issues and conducting risk mitigation activities
Evaluating and implementing novel toxicology models and assays
Addressing scientific issues using knowledge of molecular toxicology
Working closely with SD Exploratory Toxicology colleagues
Ph.D. with relevant work experience, preferred.
Advanced knowledge of general, cellular, and molecular toxicology principles.
Experience conducting mechanistic investigative studies involving signal transduction pathways, proteomics, and genomics.
Familiarity with in vitro toxicology models, assay design, validation, rationale, and mechanistic principles desired.
Familiarity with in vivo toxicology study design and conduct.
Bristol-Myers Squibb recognizes the importance of balance and flexibility in our work environment. We offer a wide variety of competitive benefits, services and programs that provide our employees the resources to pursue their goals, both at work and in their personal lives.