Translational Early Program Lead - Cardiovascular and Fibrotic Diseases at (BMS) Bristol-Myers Squibb in Princeton, New Jersey

Posted in General Business 11 days ago.

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Type: Full-Time





Job Description:

Bristol-Myers Squibb is a global Biopharma company committed to a single mission: to discover, develop, and deliver innovative medicines focused on helping millions of patients around the world in disease areas such as oncology, cardiovascular, immunoscience and fibrosis.

 

Join us and make a difference.  We hire the best people and provide them with a work environment that places a premium on diversity, integrity, collaboration and personal development. Through a culture of inclusion, we create a better, more productive work environment. We believe that the diverse experiences and perspectives of all our employees help to drive innovation and transformative business results.

Bristol Myers Squibb is a leading global biopharma company focused on discovering, developing and delivering innovative medicines for patients with serious diseases. We are focused on helping millions of patients around the world in disease areas such as oncology, hematology, immunology, cardiovascular and fibrosis.

Summary/Scope

Reporting to the Executive Director, Translational Early Development, the Translational Early Program Lead will be part of the Immunology, Cardiovascular, Fibrosis, and Global Health (ICFG) Thematic Research Center (TRC) based in Princeton or Summit, NJ. Working in a cross functional team, the individual will be responsible for the development of the clinical biomarker strategy for early stage drug development programs in cardiovascular and fibrotic diseases. This individual will also have matrixed responsibilities to guide research programs within the translational research laboratories, and will act as the translational development ICFG TRC representative in early development teams and assume primary responsibilities, such as interacting with CROs and KOLs to support contracting, sample analysis, and data delivery and interpretation of biomarkers in clinical studies.  The successful candidate will have prior experience interacting with project teams, clinical research physicians, statisticians, computational biologists, contract research organizations and translational scientists to deliver science that accelerates the development of medicines for patients in need.   

Responsibilities will include, but are not limited to, the following:


  • Responsible for managing the timelines and activities associated with clinical biomarker data delivery such as biomarker and assay selection, contracting (with support from an operations group), sample analysis, interpretation, and report generation, as well as involvement in trial-specific biomarker deliverables (e.g. biomarker plan, protocol development, study reports)

  • Work with internal translational research groups or CROs to develop and validate and selected biomarker assays for clinical implementation

  • Implements innovative translational activities in early clinical studies through direct interaction with clinical research physicians, statisticians, clinical operations, computational biologists, contract research organizations, academic experts, and internal translational scientists

  • Acts as a liaison between scientific and clinical project representatives to bridge the gap between discovery/translational research and clinical early development and enable back-translation from clinical studies to bench scientists

  • Aid in biomarker data delivery for clinical studies through working with relevant functions and CROs; supports development of SOWs and interfacing with CRO for execution of services

  • Participates in evaluation of CROs for data analysis and delivery capabilities, as needed

  • Identify and collaborate in disease or therapeutic area-specific academic/industry partnerships and consortia, with the goal of advancing scientific understanding of disease pathophysiology to enable early target and biomarker identification and validation

  • Prepares and delivers internal and external presentations

  • Supports regulatory submissions and regulatory interactions as needed

Skills/Knowledge Required


  • Experience in the relevant disease areas

  • Understanding of drug discovery and development, especially transition from preclinical to clinical stage of development

  • Experience in activities required for and related to clinical trial initiation, maintenance, and completion

  • Experience in global regulatory interactions

  • Experience in interacting with CROs and KOLs to manage projects and timelines

  • Proven scientific/leadership expertise (working in teams, mentoring people, managing projects)

  • Experience in mining of large datasets, either independently or in collaboration with bioinformaticians to understand disease pathophysiology and/or establish patient segmentation hypotheses

  • Excellent record of performance and scientific accomplishments as demonstrated by impactful contributions to the scientific community, pipeline contributions, peer reviewed publications and patent applications highly desired

  • Accountable for timelines and deliverables

  • Prioritizes risks and implements contingency plans

  • Communicates regularly; prepares and delivers presentations within the department, to governance and senior leadership bodies, and externally

  • Recognizes cross-functional issues and communicates within the larger organization. Provides expert guidance to multi-disciplinary teams and senior management. Has a track record of delivering results, driving continuous improvements, and building effective cross-functional networks.

  • Ability to prioritize and manage time efficiently

  • Strong verbal and written communication skills

  • Accurate and detailed record keeping

  • Excellent organizational skills

  • Ability to collaborate in teams and work with others in a matrixed environment

Education:

Ph.D. and 10+ years of biotechnology / pharmaceutical industry and/or relevant experience.  Candidate must be a rigorous, detail-oriented scientist, with excellent record keeping and organizational skills. Must be a highly flexible, results oriented, independent self-starter who enjoys working in a fast-paced dynamic environment.

Functional/Scientific/Technical Skills:

• Contributing to research program and business.

• Subject matter leader.

• Broad knowledge of multiple functional technologies.

• In-depth understanding of function as it relates to project.

• Functional area expert with skills, theoretical knowledge and experience to apply scientific direction and approach to projects and problems.

Tasks and Responsibilities:

• Completes technical assignments by designing, executing and interpreting complex experiments.

• Recommends department level strategic decisions.

• May lead scientifically on cross functional assignments.

• Manages and/or coordinates workflow on projects.

• Apply diverse scientific knowledge to assignments.

• Development of research tools.

• Interpret results.

Discretion/Latitude:

• Helps design operational strategies consistent with department goals.

• Provides input and makes recommendations to research strategies.

Creativity and Problem Solving:

• Identify & solve multi-faceted challenges.

• Recognizes problems and is able to recommend and develop appropriate solutions from prior experience, literature, or collaboration.

• Identify risks.

• Contributes ideas and develops/presents a scientific case (or position) inside and outside department/group.

Teamwork and Influence:

• Communicates with cross functional team.

• Directly impacts the achievement of workgroup/team goals.

• Represents workgroup/team or department on multi-disciplinary or cross functional teams.

• Work across departments.

Organizational Impact:

• Direct impact on departmental performance.

• Impact is achieved by driving team efforts.

• Able to conceptualize broad impact of research programs and personal activities

Behavioral Competencies:

• Champions change

• Leads courageously

• Networking

• Provides directions

• Structuring and staffing
• Thinks strategically

Bristol-Myers Squibb recognizes the importance of balance and flexibility in our work environment. We offer a wide variety of competitive benefits, services and programs that provide our employees the resources to pursue their goals, both at work and in their personal lives.