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Scientist, Process Chemistry Development at Millennium Pharma, Inc. in Boston, Massachusetts

Posted in General Business 30+ days ago.

Type: Full-Time





Job Description:

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Job Description

Are you looking for a patient-focused, innovation-driven company that will inspire you and empower you to shine? Join us as a Scientist in our Cambridge, MA office.

At Takeda, we are transforming the pharmaceutical industry through our R&D-driven market leadership and being a values-led company. To do this, we empower our people to realize their potential through life-changing work. Certified as a Global Top Employer, we offer stimulating careers, encourage innovation, and strive for excellence in everything we do. We foster an inclusive, collaborative workplace, in which our global teams are united by an unwavering commitment to deliver Better Health and a Brighter Future to people around the world.

Here, you will be a vital contributor to our inspiring, bold mission.

Process Chemistry & Development (PCD) is responsible for the development of robust and cost-effective processes for the manufacture of new small molecule pharmaceuticals, along with methods for achieving and controlling high standards of purity and quality.

As a Scientist working on the Process Chemistry Development (PCD) team, you will be empowered to push the boundaries of synthetic chemistry and innovate in drug development, and a typical day will include:


  • Designing and obtaining laboratory proof of concept for new, concise synthetic routes to challenging drug substance targets

  • Developing safe, efficient and robust chemical processes for drug substance manufacture

  • Partnering with our Pharmaceutical Sciences colleagues and our external supply chain to bring new experimental medicines to the clinic

  • Working in a highly collaborative and empowering environment on stimulating scientific and technical problems

POSITION OBJECTIVES:


  • Provides theoretical/conceptual input to the design, development and execution of research assignments for a specific project or projects within the functional area.

  • Independently plans and executes most unit operation characterization and optimization experiments within expertise and develops an awareness of unit operations in other areas.

  • Responsible for significant or sole technical leadership within project or complex study.

  • Prepares technology transfer documentation and regulatory documents or coordinates with team members to ensure execution.

  • Represents PCD line function on cross-functional project teams as appropriate/necessary.

  • Proactively identifies process or study issues/challenges and proposes potential resolutions.

POSITION ACCOUNTABILITIES:


  • Understands project timelines and deliverables and plans/coordinates project work accordingly with departmental, functional and external stakeholders

  • Provides technical leadership to project teams within area of expertise and commits resources to execute specific project tasks.

  • Contributes significantly and independently to project work which may include multiple projects within functional area.

  • Reviews, interprets and communicates data cross-functionally within CMC and/or project teams.  

  • Plans and implements resolutions to technical problems/issues

  • Represents functional area on cross-functional project teams by communicating activities from designated functional area to project team 

  • Supports local and global initiatives which may include leading initiatives or work streams

  • Serves as a technical resource for junior staff and leverages expertise in laboratory technology as a functional resource/trainer.

  • Independently designs and executes experiments, and reports results

  • Assists with development of project strategy and communicates complex data/decisions within department and cross functionally as necessary

  • Builds and maintains relationships with key vendors and assists with technical aspects of vendor negotiations

  • Proactively analyses manufacturing issues and coordinates potential resolution with the CMC team. 

  • Responsible for integrating scientific/technical efforts around cross-functional issues

EDUCATION, EXPERIENCE, BEHAVIOURAL COMPETENCIES AND SKILLS:  

Education and Experience:
Required:


  • PhD in Chemistry; 0+ years relevant industry experience

  • Masters degree in chemistry and 6+ years relevant industry experience 

  • Bachelors degree in chemistry and 8+ years relevant industry experience 

  • Demonstrated mastery of subject or area related to field

Knowledge and Skills:


  • In depth knowledge of modern synthetic organic chemistry.

  • Advanced proficiency in route scouting, reaction optimization, synthetic methodology development, and/or elucidation of mechanism.

  • Proficiency with analytical tools (e.g. HPLC, GC, NMR, UV, IR, MS, etc.)

  • Proficiency with utilizing typical literature searching techniques to solve organic chemistry problems

  • Analytical and Problem Solving Skills - Able to troubleshoot critical issues or problems, and determine causes and  possible solutions

  • Teamwork -- Ability to work well in highly cross functional team environment and across global line functions.

  • Communication Skills -Able to expresses one’s self clearly and concisely within team; documents issues and/or concerns concisely with colleagues; adjusts communication style as appropriate for the audience; timely and effectively communicates issues to supervisor; technical writing skills to support authorship of internal technical documents

  • Organization – Exercises good time management and prioritization skills and is able to successfully manage multiple tasks simultaneously 

  • Knowledge Sharing - Ability to capture  organizational knowledge; improve solutions, processes, and deliverables through use of information; improve information capital by contributing experience, theories, deliverables, and models for others to use

  • Resource Management -Ability to manage one’s time within individual, departmental, and corporate goals and timelines; management of internal and  external resources (vendors)

  • External Involvement – Demonstrated involvement in professional community evidenced by presentation of scientific posters or lectures at professional conferences or events

  • Technical  -  Subject matter expertise and knowledge of applicable lab equipment and operations


TRAVEL REQUIREMENTS:

May require approximately 5-10% travel.

WHAT TAKEDA CAN OFFER YOU: 


  • 401(k) with company match and Annual Retirement Contribution Plan

  • Tuition reimbursement

  • Company match of charitable contributions

  • Health & Wellness programs including onsite flu shots and health screenings

  • Generous time off for vacation and the option to purchase additional vacation days

  • Community Outreach Programs

Empowering Our People to Shine

Discover more at takedajobs.com

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Locations

Boston, MA

Worker Type

Employee

Worker Sub-Type

Regular

Time Type

Full time