Job ID: R-104196 Location: South San Francisco, CA, US 94083
Amgen is seeking a highly motivated Senior Scientist to join the Pharmacokinetics & Drug Metabolism (PKDM) department at our site in South San Francisco, California. Amgen provides a collaborative and creative culture in a company with a strong track record of innovation. Our culture encourages open dialogue and diverse views to land on the best solutions, and we help ensure our staff are equipped to excel today and tomorrow.
The department of pharmacokinetics and drug metabolism (PKDM) within Amgen is dedicated to the discovery and development of novel, effective, safe medicines. The successful candidate will work in a team environment to characterize the absorption, distribution, metabolism, excretion and pharmacokinetic properties of therapeutic drug candidates to achieve their full pharmacological potential. PKDM works in close partnership with disciplines such as pharmacology, toxicology, pharmaceutical sciences, clinical pharmacology and regulatory to design promising clinical therapeutic candidates, conduct preclinical development studies, support clinical evaluation and contribute to IND and NDA filings.
In this role you will add substantial scientific expertise to the discovery and non-clinical development of small molecule therapeutics, with a primary a primary focus on drug transporters. You will be responsible for establishing and optimizing in vitro assays to evaluate new chemical entities as substrates or inhibitors of drug transporters to assess and characterize the role of transporters in drug disposition. In addition, you will make meaningful and innovative contributions to the fundamental understanding of the role of drug transporters as they relate to absorption, distribution, and clearance of small molecule therapeutics.
In this position your core responsibilities are to:
· Serve as a functional representative and subject matter expert on the transport of small molecule therapeutics, collaborating with PBPK scientists across our PKDM scientific community
· Evaluate and implement emerging in vitro and in silico tools to support the prediction of transporter-mediated pharmacokinetics (PK) and drug interactions (DDIs) in humans
· Articulate risk and mitigation strategies for human PK and DDI predictions
· Design and complete IND and NDA-enabling studies and reports to support regulatory submissions
Your specific contributions will depend on your expertise, interests, training, and experience. You will also have opportunities to learn and obtain experience with PKDM strategies for the discovery and non-clinical development of biological therapeutics.
In addition to the core responsibilities, the position provides the opportunity to pursue scientific inquiries into the fundamental physiological and biochemical factors that determine the absorption, distribution, and clearance of protein therapeutics. A collaborative and highly capable scientific community at Amgen is available to support these efforts. Interactions and collaboration with academic and other external scientists are encouraged.
Doctorate degree and 2 years of Scientific experience
Master's degree and 5 years of Scientific experience
Bachelor's degree and 7 years of Scientific experience
· A Ph.D. in pharmaceutical, chemical, or biological science (or BA/MS with equivalent experience)
· Expertise with implementing, optimizing and troubleshooting in vitro transporter assays.
· Knowledge of PK and distribution of small molecule therapeutics.
· Critical thinking and demonstrated ability to communicate with team members across broad disciplines.
· Effective oral and written communication skills are essential.
We understand that to successfully sustain and grow as a global enterprise and deliver for patients - we must ensure a diverse and inclusive work environment.
If you're seeking a career where you can truly make a difference in the lives of others, a career where you can work at the absolute forefront of biotechnology with the top minds in the field, you'll find it at Amgen.
Amgen, a biotechnology pioneer, discovers, develops and delivers innovative human therapeutics. Our medicines have helped millions of patients in the fight against cancer, kidney disease, rheumatoid arthritis and other serious illnesses.
As an organization dedicated to improving the quality of life for people around the world, Amgen fosters an inclusive environment of diverse, ethical, committed and highly accomplished people who respect each other but compete intensely to win. Together, we live the Amgen values as we continue advancing science to serve patients.
Amgen is an Equal Opportunity employer and will consider all qualified applicants for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, protected veteran status, or disability status.
Amgen will consider for employment qualified applicants with criminal histories in a manner consistent with the San Francisco Fair Chance Ordinance.PI123693685