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Bioinformatics Analyst at J. Craig Venter Institute (JCVI) in La Jolla, California

Posted in General Business 30+ days ago.

Type: Full-Time





Job Description:

Position Summary

The Cheng lab at JCVI is looking for a highly motivated Bioinformatics Analyst. Dr. Cheng’s lab is interested in the development of a comprehensive understanding of the gene regulatory network and how aberrant regulatory circuits contribute to human disease. Her group carries out both wet-lab (experimental) and dry-lab (computational) research and utilize single cell transcriptomics and epigenetics to understand dysregulated gene regulatory circuitry in opioid use disorder and Alzheimer’s disease.

Essential Functions


  • Data analysis and interpretation of single cell functional genomic datasets.

  • Develop computational methods to analyze single cell genomics datasets.

  • Documentation and present results to lab members and collaborators.

  • Prepare figures for scientific papers.

  • Analysis and synthesis activities including: interpreting and analyzing biological information derived from genome annotation; performing tasks to reduce and consolidate output from software; preparing data and reports for utilization by other scientists. Examples may include:

    • Data mining and analysis including using various internal resources, public databases and maintaining knowledge of appropriate scientific literature.

    • Performing statistical analysis.

    • Performing comparative analysis.



  • Public resource development including: integrating genomic data with external data sources to facilitate the sharing of genomic and proteomic data with the community. Examples may include:

    • Collecting and curating primary data.

    • Creating and populating database tables and/or websites.

    • Integrating data into a database or a larger project.



  • Works under direct supervision and direction of Dr. Cheng, to execute bioinformatics assignments to meet project goals. Must be able to work independently accordingly to experience, exercising analytical judgment and involving supervisory personnel where appropriate.

  • The dimensions upon which an Analyst’s established capabilities and professional growth will be judged are based on the ability to:

    • Execute complex tasks effectively with limited supervision.

    • Provide project leadership and mentoring beyond the scope of their own work, including leadership of small ad-hoc project teams.

    • Define and estimate scope of tasks prior to implementation.

    • Execute projects within estimated time frames.



  • Develops and maintains an understanding of the scientific and biological domain supported by the team, as well as bioinformatics tools, software, and IT technologies used by the team.

  • Collaborates closely and effectively with software, bioinformatics, scientific, information technology, and administrative personnel within and outside the Institute to accomplish goals. Is an effective member of annotation and other multi-disciplinary teams.

  • Abides by environmental, health and safety policies and procedures. This includes reporting potential hazards and when necessary helping to implement solutions to ensure safety and respect for the environment.

  • Performs other duties as assigned.

  • Strictly adheres to all documented JCVI policies and procedures to include carrying out all functions required of Institute employees (i.e. completion of timesheets in an accurate and timely manner).

Prerequisites


  • Bachelors or Master’s or PhD degree in Bioinformatics, Statistics, Computational Biology or related fields.

  • Excellent programming skill, for example, in R, Python and Unix/Linux.

  • Team oriented with excellent written and verbal communication skills.

  • Training or experience in NGS, functional genomics data analysis preferred.

  • Solid knowledge of molecular biology as it relates to DNA sequences, sequencing technologies and genomics.

  • Strong written and verbal communication skills.

  • Excellent organization and time management skills and ability to meet schedules.

  • Ability to collaborate across a multi-disciplinary team, and work independently.

Work Environment
The work environment characteristics described here are representative of those a teammate encounters while performing the essential functions of this job. Reasonable accommodations may be made to enable individuals with disabilities to perform the essential functions.


  • Moderate noise (i.e. business office with computers, phone, and printers, light traffic).

  • Ability to work in a confined area.

  • Ability to sit at a computer terminal for an extended period of time.

Physical Demands
The physical demands described here are representative of those that must be met to successfully perform the essential functions of this job. Reasonable accommodations may be made to enable individuals with disabilities to perform the essential functions.


  • While performing the duties of this job, the employee is regularly required to, stand, sit; talk, hear, and use hands and fingers to operate a computer and telephone keyboard reach, stoop kneel to install computer equipment.

  • Specific vision abilities required by this job include close vision requirements due to computer work.

  • Light to moderate lifting is required.


This job description is not designed to cover or contain a comprehensive listing of activities, duties or responsibilities that are required of the employee

.