Postdoctoral Fellow - PhD (Parish Lab) at Seattle Children's Hospital in Seattle, Washington

Job Description:

About Us
Hope. Care. Cure. These three simple words capture what we do at Seattle Children's - to help every child live the healthiest and most fulfilling life possible. Are you ready to engage with a mission-driven organization that is life-changing to many, and touches the hearts of all? #HOPECARECURE

As one of the nation's top five pediatric research centers, Seattle Children's Research Institute is dedicated to providing hope, care, and cures to help every child live the healthiest and most fulfilling life possible.

Our investigators are involved in hundreds of projects that cover every phase of research, from studying how diseases work to improving investigational therapies. They have pioneered groundbreaking cystic fibrosis treatments and cutting-edge cancer therapies that help a child's immune system defeat cancer, and made other major contributions to pediatric medicine.

Researchers work in close collaboration with one another, their colleagues at partner institutions including the and and our healthcare providers at Seattle Children's Hospital, one of top children's hospitals. This collaboration is one of our key strengths, allowing our faculty to draw on a variety of disciplines and techniques as they pursue solutions to some of medicine's most complex problems.

We are committed to not only treating disease but to eliminating it. Help us achieve our vision of being a worldwide leader in pediatric research aimed to improve the health and well-being of children. If you are interested in a challenging career aimed at groundbreaking research, Seattle Children's Research Institute is the place for you.
Overview
TB remains a serious global health problem and there is an urgent need for new therapeutic agents. The Parish Lab (https://www.linkedin.com/in/tanya-parish-a564056/) is looking for a post-doctoral scientist to work on a tuberculosis drug discovery project. The successful candidate will work in a multi-disciplinary research environment, interacting with chemists and microbiologists on multiple projects. The candidate will work on a research project to develop novel inhibitors of respiration in the global human pathogen Mycobacterium tuberculosis; they will also conduct research into mode of action of new inhibitors.

Description of Responsibilities:

- Conduct a research and development project

- Design and implement research plans

- Troubleshoot and solve experimental and technical problems

- Prepare and present papers, reports, and presentations of current research work

- Write manuscripts and assist with grant preparation

- Oversee quality control and data integrity

- May supervise one or more research assistants

Specific duties include:

- Work under Biosafety Level 3 conditions with Mycobacterium tuberculosis

- Characterization and development of small molecules as candidate anti-tubercular agents using a wide range of microbiological and cellular assays.

- Determine mechanism of kill and resistance mechanisms for new anti-tubercular agents targeting respiration.

- Conduct in vitro drug combination studies with new anti-tubercular agents.
Requirements
Required Education/Experience:
- PhD in specialty area from an accredited university training program
- Experience using basic research techniques of specialty area

Preferred:
- Previous experience conducting research in the pediatric arena
- Experience in protocol and manuscript development and in grant writing
Our Commitment to Diversity
Our community welcomes diverse experiences, backgrounds, and thoughts as this is what drives our spirit of inquiry and allows us to better connect with our increasingly diverse patients and families. Our organization recruits, employs, trains, compensates, and promotes without regard to race, religion, color, national origin, gender (including pregnancy, childbirth, or related medical conditions), sexual orientation, gender identity, gender expression, age, status as a protected veteran, status as an individual with a disability, or other applicable legally protected characteristics.

The people who work at Seattle Children's are members of a community that seeks to respect and celebrate all the qualities that make each of us unique. Each of us is empowered to be ourselves within this community, which cultivates and promotes equity, diversity, and inclusion at all levels.

Seattle Children's is proud to be an Equal Opportunity Workplace and Affirmative Action Employer.

- Area of Interest: Research & Development;
- FTE/Hours per pay period: 1.0 FTE (80 hours per bi-weekly pay periods);
- Work Status: Regular;
- Department: Global Infectious Disease;
- Shift: Day Shift;
- Job ID: 35389;.