Associate Scientist II, Translational Research at Alnylam Pharmaceuticals in Cambridge, Massachusetts

Posted in General Business 1 day ago.

Type: Full-Time

Job Description:

Associate Scientist II, Translational Research


Alnylam is the world's leading RNA interference (RNAi) company.

Founded in 2002, Alnylam was built upon a bold vision of turning scientific possibility into reality by harnessing the power of RNAi for human health as an innovative new class of medicines. We are a growing biopharmaceutical company with three approved medicines and a robust pipeline of investigational medicines focused in four strategic therapeutic areas: genetic medicines, cardio-metabolic diseases, infectious diseases, and central nervous system (CNS) and ocular diseases, including several in late-stage development.

Headquartered in Cambridge, Mass., Alnylam employs over 1,500 people in 19 countries and is rapidly growing globally, with additional offices in Norton, Mass., Maidenhead, U.K., Zug, Switzerland, Amsterdam, Netherlands, and Tokyo, Japan. Alnylam is proud to have been recognized as one of The Boston Globe's Top Places to Work six years in a row (2015-2020), a Great Place to Work in the U.K. and Switzerland two years in a row (2019-2020) and a Science Magazine's Top Employer two years in a row (2019-2020). Please visit for more information.

We are currently seeking a talented candidate to fill an Associate Scientist II position within Alnylam's Research department. The successful candidate will support development of current therapeutic programs the rare disease and metabolic space as part of a multidisciplinary team and be involved in the discovery of RNAi compounds for a variety of novel indications and support their entry into the clinic. The successful candidate will have a strong background in biological sciences and be technically skilled in protein/mRNA analysis. Experience or willingness to learn in vivo rodent techniques is also required. Passion for science, attention to detail and a desire to learn new techniques are a must.

Summary of Key Responsibilities

  • Execute studies to explore and characterize molecules for RNAi therapeutic programs
  • Conduct assays that support in vivo studies, such as qPCR and ELISA
  • Perform in vivo procedures, including administration of therapeutics via established methodologies
  • Perform in vitro and cell-based assays to further characterize drug activity
  • Analyze and interpret the data
  • Prepare clearly articulated experimental reports and data presentations
  • Prepare of SOPs/protocols
  • Present data to groups within and outside of Research


  • B.S/M.S. degree in a biological discipline such as Molecular Biology, Cell Biology, or Genetics
  • 1-3 years of post-degree research experience in an industrial or academic setting
  • Experience in RNA/DNA/protein analysis techniques, including ELISA and qPCR
  • Basic rodent in vivo skills: animal handling, subcutaneous/intravenous dosing, blood collection, and necropsy/dissection expertise
  • Cell/tissue culture and flow cytometry are a plus
  • Ability to perform assays independently and troubleshoot assays with direction of supervisor(s)/project leader(s)
  • Demonstrate keen knowledge of experimental design, underlying scientific principles, and the ability to rigorously and independently analyze results, propose future directions and generate clear reports
  • Must be flexible, open to new tasks and challenges and able to work on tight deadlines
  • Capacity to multi-task
  • Proven ability to work in a team environment
  • Good team player attributes; strong interpersonal skills

Alnylam Pharmaceuticals is an EEO employer committed to an exciting, diverse, and enriching work environment.