Scientist - Antibody Drug Conjugates at AstraZeneca in Gaithersburg, Maryland

Posted in Other 16 days ago.

Job Description:

Do you have a passion for Science? Would you like to apply your expertise to impact a company that follows the science and turns ideas into life changing medicines? Then AstraZeneca might be the one for you!

At AstraZeneca, we put patients first and strive to meet their unmet needs worldwide. Working here means being entrepreneurial, thinking big and working together to make the impossible a reality. If you are swift to action, confident to lead, willing to collaborate, and curious about what science can do, then you're our kind of person.

About AstraZeneca in Gaithersburg, MD

Our Gaithersburg, Maryland facility creates life-changing medicines for people around the world. This campus employs more than 3,500 experts in our field and is only a short drive from Washington, DC. This modern and vibrant scientific campus is the home of R&D and Oncology in the US. Here, we play host to some of the most cutting-edge technology and lab spaces, all designed to inspire collaboration and cross-functional science. We believe employees benefit from being challenged and inspired at work. We are dedicated to creating a culture of inclusion and collaboration.

The Gaithersburg site offers a variety of amenities to help boost productivity and help keep our employees happy and healthy. This includes a fitness center, employee healthcare clinic, electric vehicle charging stations, dry cleaning, full-service cafeteria and copy center. This is where you'll find newly-designed, activity-based work spaces to suit a variety of working styles while increasing collaboration between teams.

Summary of the Group

Antibody Discovery & Protein Engineering (ADPE) is responsible for the discovery and optimization of next generation biologics to create biological drug candidates for all key therapeutic areas such as oncology, respiratory and inflammation, cardiovascular, renal and metabolic diseases. We're constantly pushing the boundaries of science to deliver life-changing medicines to patients, with a pass for the development of in-house biologics discovery platforms and novel drug modalities to address unmet medical needs.

Main Duties & Responsibilities
  • Design and perform drug conjugation experiments to support antibody drug conjugate (ADC) pipeline and technology development
  • Use FPLC to purify mg to gram scale conjugates using various chromatography techniques.
  • Perform biochemical and biophysical characterization of ADCs
  • Develop and optimize novel conjugation and purification methodologies, including high-throughput conjugation and purification.
  • Strong capability in experimental design and data analysis skills
  • Effectively present data internally and externally

Education & Experience Requirements

Bachelor's or Master's degree in Biotechnology, Chemical Biology, Biochemistry, Chemistry, or other relevant scientific field with 4+ years (BS degree) or 2+ years (MS degree) of relevant experience.

Required Skills
  • Hands-on experience in protein labeling and/or drug bioconjugation from mg to gram scale.
  • Hands-on experience in purifying large scale conjugates using HIC, IEX, SEC and affinity chromatography using AKTA or other FPLC.
  • Experience in analytic methods such as SEC, HIC, IEX, LC-MS, DLS, RP-HPLC, etc.
  • The ability to learn new technologies quickly and ability to perform in a fast-paced, matrix-structured work environment
  • Great teamwork, communication, and interpersonal skills

Desired Skills
  • Experience with routine DNA/RNA techniques, protein expression and purification
  • Experience with mammalian cell culture techniques
  • Experience in in vitro cell killing assays with ADCs
  • Good knowledge in antibody engineering and therapeutics

Why AstraZeneca?

At AstraZeneca when we see an opportunity for change, we seize it and make it happen, because any opportunity no matter how small, can be the start of something big. Delivering life-changing medicines is about being entrepreneurial - finding those moments and recognising their potential. Join us on our journey of building a new kind of organisation to reset expectations of what a bio-pharmaceutical company can be. This means we're opening new ways to work, pioneering cutting edge methods and bringing unexpected teams together. Interested? Come and join our journey.

So, what's next?

Are you ready to bring new ideas and fresh thinking to the table? Brilliant! We have one seat available and we hope it's yours.

Where can I find out more?

Our Social Media, Follow AstraZeneca on LinkedIn

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