Scientist, Medicinal Chemistry at Neurocrine Biosciences in San Diego, California

Posted in Other 21 days ago.

Job Description:

Who We Are:

At Neurocrine Biosciences, we pride ourselves on having a strong, inclusive, and positive culture based on our shared purpose and values. We know what it takes to be great, and we are as passionate about our people as we are about our purpose - to relieve patient suffering and enhance lives.

What We Do:

Neurocrine Biosciencesis a neuroscience-focused, biopharmaceutical company with 28 years of experience discovering and developing life-changing treatments for people with serious, challenging and under-addressed neurological, endocrine and psychiatric disorders. The company's diverse portfolio includes FDA-approved treatments for tardive dyskinesia, Parkinson's disease, endometriosis* and uterine fibroids*, with three pivotal and five mid-stage clinical programs in multiple therapeutic areas. Headquartered inSan Diego,Neurocrine Biosciencesspecializes in targeting and interrupting disease-causing mechanisms involving the interconnected pathways of the nervous and endocrine systems. (*in collaboration with AbbVie)

About the Role:

Responsible for the design, synthesis, purification, and characterization of intermediates and bioactive compounds through the use of techniques such as column chromatography (e.g., high performance liquid chromatography, automated normal phase purification), nuclear magnetic resonance and parallel or combinatorial synthesis. Prepares technical reports, summaries, protocols, and quantitative analyses. Responsible for the communication and presentation of results to the project team in order to facilitate effective decision making.


Your Contributions (include, but are not limited to):

  • Plays key role in the rapid optimization of lead molecules utilizing modern technology available to medicinal chemists such as automated synthesis and purification.

  • Participates in a multidisciplinary team committed to the continuous improvement of the lead optimization process as well as the expeditious identification of development compounds.

  • Designs, plans and conducts synthesis of intermediates and analog libraries as well communicates results to the project or program team.

  • Other duties as assigned.


  • PhD in Synthetic Organic Chemistry or related field preferred and some related postdoctoral experience required; 2+ years postdoctoral experience preferred OR

  • MS/MA degree in Synthetic Organic Chemistry preferred and some similar experience noted above, OR

  • BS/BA degree and 2+ years of relevant experience, including familiarity utilizing any or all of the following: parallel synthesis, lab automation, and purification in the optimization of lead compounds is preferred

  • Working knowledge of any or all of the following: organic synthesis, parallel synthesis, medicinal chemistry, lab automation, and purification in the optimization of lead compounds is preferred

  • Recognizes fundamental anomalies in data points and identifies issues in experiments / processes

  • Begins to understand how to think outside of the technical process and consider the impact decisions will have on the broader scientific goals

  • Strong knowledge of scientific discipline

  • Good knowledge of scientific principles, methods and techniques

  • Good knowledge and demonstrated ability working with a variety of laboratory equipment/tools

  • Strong computer skills

  • Good problem-solving, analytical thinking skills

  • Detail oriented

  • Ability to meet deadlines

  • Excellent communication skills with the ability to collaborate with cross-functional scientists

Neurocrine Biosciences is an EEO/AA/Disability/Vets employer.