Scientist II at Sarepta Therapeutics in Cambridge, Massachusetts

Job Description:

The RNA Research group at Sarepta Therapeutics is seeking a talented, motivated, and experienced scientist to join the chemistry team in Cambridge, MA. The successful candidate will work on our PMO oligonucleotide platform and discovery research on improved delivery of oligonucleotides as well as manage collaborations and CROs as needed. This position will work closely with Discovery Biology, Translational Sciences, and Business Development teams to implement new programs and manage changes.

Primary Responsibilities:

• Establish oligonucleotide synthesis, conjugation, and delivery platform: Design and conduct novel oligonucleotide conjugates synthesis, purification, and characterization; Apply state-of-the-art delivery methods to achieve in vivo proof of concept; Develop efficient and scalable synthetic methods and routes.


• Act as key member of a multidisciplinary drug delivery team, assisting with development of project strategy, and analysis and communication of complex data.


• Serves as an in-house oligonucleotide and delivery chemistry expert.


• Drive the writing of technical reports to support patent applications and manuscript preparations.


• Organize workstreams and complete individual and team objectives to maintain project timelines.


• Supervise and mentor junior staff.

Qualifications and Experience:

• PhD in organic chemistry, biochemistry, or related fields with 4+ yrs of relevant post-doctoral experience; or M.S. with 8+ yrs experience


• Hands-on experience in nucleic acid, peptide, and bioconjugation research


• Previous experience in the design, chemical optimization, and formulation/delivery of oligonucleotide therapeutics is highly desired


• Experience in developing and utilizing analytical methods for oligonucleotides characterization


• Track record with the ability to execute multiple concurrent research projects within a cross-functional team environment


• Excellent communication, presentation, and interpersonal skills

Candidates must be authorized to work in the U.S.

Sarepta offers a competitive compensation and benefit package.

Sarepta is an Equal Opportunity/Affirmative Action employer and participates in e-Verify.