Associate Software Engineer - GTEx/GRO at Broad Institute in Cambridge, Massachusetts

Posted in Other 3 days ago.

Job Description:

Job Description

The Broad Institute is launching a new effort, the "Gene Regulation Observatory" (GRO). The mission of the GRO is to deeply understand fundamental processes of genome regulation in single cells, and spans interests from many of the Broad's programs and communities, including the Epigenomics & Cell Circuits, MPG, and Stanley center programs and communities.

The Genotype-Tissue Expression (GTEx; group at the Broad Institute is looking for exceptional candidates to join these efforts, with a focus on characterizing how genetic variation regulates gene expression across human cell types and tissues, towards the goal of characterizing the function of genetic variants and genes in human diseases and traits. The successful candidate will join an interdisciplinary team working with an unprecedented set of sequencing data from a wide range of human tissues and cell types, including from state-of-the-art multi-omic single-cell assays.

We are looking for a full-stack software engineer to help us design and build a robust data portal that enables researchers across the world to accelerate advances in scientific understanding. The GTEx Portal is used by researchers, pharmaceutical companies, and clinicians to search, download, and visualize our gene expression and quantitative trait loci data. The GTEx Portal is a modern, cloud-based web application deployed on the Google Cloud Platform, with REST-style services and an innovative JavaScript and D3.js user interface.

We are looking for individuals who are enthusiastic about taking a hands-on, problem-solving approach, and collaborating with scientists and engineers in an informal and collegial work environment that is infused with intellectual rigor. The right candidate will have an outstanding academic record and strong communication skills, and will demonstrate innovative and analytical thinking. The Broad Institute provides a vibrant research environment with close links to MIT, Harvard, and the Harvard-affiliated hospitals across Boston. The position provides the potential for your contributions to be utilized and recognized across a global network of researchers participating in these efforts, and by the thousands of monthly users of the GTEx Portal.

Characteristic Duties

  • Work in a collaborative setting with a small team of developers and computational biologists to enhance the GTEx Portal.

  • Design and implement a high-quality, production-grade, full-stack web portal.

  • Deploy applications to the cloud and monitor health.

  • Design and implement data models.

  • Design and implement RESTful web services.

  • Participate in code reviews and apply feedback to subsequent work.

  • Proactively identify obstacles or problems and recommend improvements.

No genomics or biology background is required, just an enthusiasm to contribute to advances in scientific understanding of biology and an ability to write exceptional software in an environment that is highly responsive to our user community.


  • Undergraduate degree in computer science or related field.

  • Proficient in Python, JavaScript, HTML5, and CSS.

  • Full-stack web development experience.

  • Excellent oral and written communication skills.

  • Knowledge of biology/genetics is not required, though it is a plus.


All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, disability or protected veteran status.

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