Research Tech III - Lefebvre Laboratory-- SOX transcription factors at Children's Hospital of Philadelphia in Philadelphia, Pennsylvania

Job Description:

Location:LOC_ABRAMSON-Abramson Building

Req ID:129131

Shift: Any

Employment Status:Regular - Full Time

Job Summary

TheLefebvre Labis seeking an experienced research technician to participatein planned research projects by performing research protocols and experimental procedures and analyzing data underminimal supervision.

Skeletal and brain diseases occur in many forms with variable degrees of severity. At one end of the spectrum are rare congenital malformations severely reducing life expectancy or quality of life. At the other end are adult-onset degenerative diseases like osteoporosis, osteoarthritis, and dementia. Despite some recent developments, treatment options and cures are still missing or insufficient for most of these diseases. Research is needed to find novel strategies to prevent, effectively treat, or cure these diseases.

Research in the Lefebvre Lab focuses on advancing the fundamental understanding of the genetic mechanisms whereby specific cell types acquire the unique and challenging functions of developing highly sophisticated and specialized structures as the skeleton and brain in early life, and keeping these structures healthy throughout life. These cells include skeletal progenitor/stem cells, chondrocytes, osteoblasts, and neocortical neurons.

The laboratory has a long track record of deciphering how members of SOX transcription factor family drive the genetic programs that determine the identity and differentiated activities of these cells and how these factors are themselves controlled by regulatory networks. In addition to these fundamental science projects, the Lefebvre Lab also works on translational projects aimed at uncovering the mechanisms whereby de novo, heterozygous mutations in SOX genes lead to SOXopathies; that is, a family of rare human developmental syndromes impacting various systems, including the skeleton and brain. The main goal of the lab is to find ways to treat children born with these diseases and give them and their loved ones the best possible chances at life.

Experimental approaches in the lab include state-of-the-art techniques and include mouse models; cell reprogramming and differentiation assays in vitro; high-throughput sequencing approaches for chromatin, RNA, and protein; and various software programs for large data mining and analysis.

To lean more aboutthe lab clickhere :

https://www.research.chop.edu/lefebvre-laboratory

Job Responsibilities

• Performs research procedures on experimental samples with minimal supervision


• Formulates and performs complex lab experiments and analyzes & reports the data


• Performs tasks that require knowledge of advanced techniques and equipment


• Performs advanced calculations and maintains appropriate log and lab notebooks


• Assists with planning specific research protocols and procedures


• Assists in development & troubleshooting of new techniques and ideas


• May be required to modify scientific methods and protocols (in conjunction with PI)


• Checks others results for completeness and accuracy


• May be responsible for training and mentoring new staff


• Assists in the preparing of grants journal articles, poster and oral presentations


• May perform routine and non-routine tests / experiments as needed

Required Licenses, Certifications, Registrations

None

Preferred Education, Experience & Cert/Lic

Preferred Education: Bachelor's Degree

Preferred Experience: Two (2) years of laboratory experience

Additional Technical Requirements

All CHOP employees who work in a patient building or who provide patient care are required to receive an annual influenza vaccine unless they are granted a medical or religious exemption.

Children's Hospital of Philadelphia is committed to providing a safe and healthy environment for its patients, family members, visitors and employees. In an effort to achieve this goal, employment at Children's Hospital of Philadelphia, other than for positions with regularly scheduled hours in New Jersey, is contingent upon an attestation that the job applicant does not use tobacco products.

Children's Hospital of Philadelphia is an equal opportunity employer. We do not discriminate on the basis of race, color, gender, gender identity, sexual orientation, age, religion, national or ethnic origin, disability or protected veteran status.

VEVRAA Federal Contractor/Seeking priority referrals for protected veterans. Please contact our hiring official with any referrals or questions.

CHOP Careers Contact

Talent Acquisition

2716 South Street, 6th Floor

Philadelphia, PA 19146

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