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Research Associate I, Biology at PTC Therapeutics, Inc. in Bridgewater, New Jersey

Posted in Science 30+ days ago.

Type: Full-Time





Job Description:

Job Description Summary:

The Research Associate I, Biology will be responsible for conducting scientific experiments and other drug discovery activities at PTC in advancement of PTC’s gene therapy programs in the field of rare genetic disorders. The incumbent will be participating in the production, purification and characterization of recombinant AAV-based vectors.

The Research Associate I, Biology is also responsible for communicating experimental results to his/her supervisor and the project team and is obligated to adhere to all regulatory requirements and company Standard Operating Procedures (SOPs) including as appropriate. 

Job Description:

ESSENTIAL FUNCTIONS

Primary duties/responsibilities:


  • Under general guidance, executes experiments, analyzes results, and communicates them as part of AAV production team within the Gene Therapy group.


  • Uses in-house established methods to produce rAAV vectors for in vivo efficacy and pharmacology studies.


  • Participates in the development of new methods and optimization of the existing methods for AAV production in-house.


  • Assists the team in characterization of the produced rAAV vectors, including determining the titer, purity, and the transduction activity of the produced vectors.


  • Applies relevant scientific principles and techniques to research problems.


  • Maintains detailed laboratory notebooks.


  • Presents findings internally and contributes to the publication of the work of the project team.


  • Complies with all safety requirements.


  • Contributes to laboratory needs, such as stock room maintenance and ordering supplies.


  • Involved in general lab duties as assigned.


KNOWLEDGE/SKILLS/ABILITIES REQUIRED


  • Human tissue culture experience is required.


  • Knowledge of and ability to use standard molecular and cell biology techniques.


  • DNA transfection.


  • DNA and RNA purification and quantification, qPCR.


  • Western blotting, ELISA, HTRF, reporter assays.


  • Strong communication skills


  • Proficiency with Microsoft Office- preferably MS Excel and MS PowerPoint.


  • Ability to work collaboratively under direct supervision, in a fast-paced, matrixed, team environment.


  • Excellent planning, organization, and time management skills


* Minimum level of education and years of relevant work experience.

  • Bachelor’s degree in a scientific discipline with 0-2 years of research experience.

* Travel requirements

None

*Physical requirements (only note if the job requires physical capacity beyond general office work)

Laboratory based position

EEO Statement:

PTC Therapeutics is an equal opportunity employer. We welcome applications from all individuals, regardless of race, color, national origin, gender, age, physical characteristics, social origin, disability, religion, family status, pregnancy, sexual orientation, gender identity, gender expression, disability, veteran status or any unlawful criterion under applicable law. We are committed to treating all applicants fairly and avoiding discrimination.

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