Scientist/Sr Scientist, Protein Sciences at Broad Institute in Cambridge, Massachusetts

Posted in Other 14 days ago.

Job Description:

Job Description


The Broad Institute is an amazing place - we exist to apply our deep knowledge of human genetics to empower a revolution in biomedicine and accelerate the pace at which the world conquers disease. The Broad Institute's Center for the Development of Therapeutics (CDoT) and its team of professional "drug hunters" partner with faculty at MIT, Harvard, and the Harvard teaching hospitals to translate emerging biological insights into novel therapeutic strategies. We couple novel technologies and approaches to industry-standard drug discovery rigor to tackle some of the most challenging targets across a wide range of disease areas (including oncology, cardiovascular disease and diabetes, psychiatric disease, infectious disease).

We are currently seeking a highly motivated and talented protein scientist/biochemist/biophysicist capable of leading drug discovery project teams and/or driving therapeutic discovery at the bench through the expression, purification, and characterization of therapeutic protein targets. The successful candidate will have multiple experiences in the construction of expression vectors, expression and purification of recombinant proteins, and biophysical and functional analysis of recombinant proteins and their interactions with partner proteins and/or small molecules. Experience in structural biology is advantageous.


  • Design and construction of expression vectors for recombinant protein expression

  • Design, execution, and optimization of protocols to express recombinant proteins in bacterial, insect, and/or mammalian cells

  • Characterization of recombinant proteins, protein-protein interactions, and protein-compound interactions through biophysical techniques and functional assays

  • Interpreting experimental outcomes and proposing next steps

  • Troubleshooting technical and scientific problems

  • Documenting work and effectively presenting results to multi-disciplinary project teams

  • Working in partnership with team members and collaborators to best achieve results

  • Managing and mentoring research associates

  • Providing technical expertise on a project team

  • Depending on experience, leading or co-leading therapeutic projects


  • Ph.D. in Biochemistry, Biophysics or a related life science field with at least 2 years post-PhD research experience in an industrial or academic setting

  • Experience with molecular cloning and vector construction, bacterial expression, and protein purification through conventional and affinity-based chromatographic approaches is required

  • Experience with insect and/or mammalian cell expression is advantageous

  • Experience in the functional characterization of recombinant proteins and biophysical characterization of protein-protein and/or protein-small molecule interactions is required

  • Experience in protein crystallography, cryo-EM, or NMR is advantageous

  • Experience with production and/or engineering of antibodies is advantageous

  • A proven record of successful interaction with project team members, external customers or vendors is advantageous

The successful candidate will be a results-focused, team-oriented scientist able to excel in a fast-track environment across multiple projects. They must be accountable, self-motivated, detail-oriented and exhibit problem solving skills. In addition, the successful candidate will be a clear and effective communicator, demonstrating strong interpersonal skills to enable collaboration with team members.


  • Normal laboratory conditions

  • Normal office conditions


All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, disability or protected veteran status.

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