Translational Sciences Senior Research Associate I at Takeda Development Center Americas, Inc. in Boston, Massachusetts

Job Description:

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Job Description

Are you looking for a patient-focused, innovation-driven company that will inspire you and empower you to shine?

At Takeda, we are transforming the pharmaceutical industry through our R&D-driven market leadership and being a values-led company. To do this, we empower our people to realize their potential through life-changing work. Certified as a Global Top Employer, we offer stimulating careers, encourage innovation, and strive for excellence in everything we do. We foster an inclusive, collaborative workplace, in which our global teams are united by an unwavering commitment to deliver Better Health and a Brighter Future to people around the world.

Here, you will be a vital contributor to our inspiring, bold mission.

Takeda is proud in its commitment to creating a diverse workforce and providing equal employment opportunities to all employees and applicants for employment without regard to race, color, religion, sex, sexual orientation, gender identity, gender expression, parental status, national origin, age, disability, citizenship status, genetic information or characteristics, marital status, status as a Vietnam era veteran, special disabled veteran, or other protected veteran in accordance with applicable federal, state and local laws, and any other characteristic protected by law.

OBJECTIVES/PURPOSE

• Serve in an exciting role as a laboratory senior research associate that directly supports our cutting-edge drug discovery programs across our immune oncology pipeline.


• Develop & execute tissue slide-based assays & perform detailed analyses that drive drug target discovery/development efforts through the identification of mechanisms of action, pharmacodynamic markers and predictive biomarker signatures.


• Interact with stake-holders across the department as well as external vendors.


• Be part of a rapidly-evolving team that is working to bridge drug discovery with clinical development to move our most impactful programs forward in ways that meaningfully improve patient outcomes in the clinic.

We are a rapidly evolving translational research laboratory that is uniquely situated between the oncology drug discovery & clinical units of Takeda. Our goal is the implementation of innovative cell phenotyping capabilities that reveal unique biomarkers and mechanisms of action that are critical to driving the development of next generation immune-modulatory drugs for the treatment of cancer. In this position, you will be embedded within the early Translational Oncology group to help drive the development of tissue-based assays and provide laboratory expertise in a multitude of ways that support next-generation immune-oncology drug development.

ACCOUNTABILITIES

• Develop and execute singleplex and multiplex immunohistochemistry/immunofluorescence assays.


• Conduct tissue image analyses on stained tissues from preclinical and clinical samples.


• Incorporate proper quality controls and best practices to produce high-quality work in an efficient manner.


• Complete all assigned laboratory duties in a timely-manner and effectively resolves technical issues.


• Communicate and collaborate effectively with departmental colleagues and external partners in a cross-functional, highly-collaborative team environment.


• Appropriately document testing and record data in our electronic notebook.


• Responsibilities include ~80% lab work and ~20% collaboration with our oncology teams.


• Demonstrates strong working knowledge of immunohistochemistry and immunohistochemistry as performed on Ventana Ultra and Leica Bond autostainers.


• Independently conduct multiple complex experiments and/or tasks within the project scope while exercising good technical judgement to assure high quality testing and results.


• May help train new junior staff when appropriate.


• Recognizes problems related to samples, reagents, equipment, software, methods, and/or processes. Demonstrates a degree of independence in troubleshooting, providing technical guidance, and/or seeking out expertise for proper resolution.


• Participates in interactions and collaborations across our ODDU and translational science programs and teams.


• Prepares and presents technical information at laboratory and department meetings when required.


• Potential to attend and present data directly to program teams for expand project involvement.


• Receives high level instructions on work and then independently designs, develops, and executes in situ assignments.

• BS with 4-6+ years experience in an academic and/or industry setting related to immunohistochemistry, target validation, mechanism of action, pharmacodynamic, and translational strategies for immuno-oncology and antibody based therapeutics.


• Excellent oral and written communication skills.


• Ability to work within multi-disciplinary and matrixed teams.


• Good fit with Takeda core values and leadership principles.


• Right attitude (agile, curious, open-minded, "can-do" mindset).


• Effective time management skills.


• Experience in automated IHC/IF assay development (Lieca, Ventana) and analysis of markers in human and animal tissue specimens is strongly preferred.


• Knowledge of oncology biology, including immuno-oncology.


• Experience in image analysis (HALO software) desirable but not required.

• 401(k) with company match and Annual Retirement Contribution Plan


• Tuition reimbursement Company match of charitable contributions


• Health & Wellness programs including onsite flu shots and health screenings


• Generous time off for vacation and the option to purchase additional vacation days


• Community Outreach Programs

• This role is considered a hybrid position and you must be able to work onsite in Cambridge, MA on average 2-3 days per week.

Absent an approved religious or medical reason, all US office-based and lab-based Takeda employees who work fully on-site or in a hybrid model (as determined by Takeda) must be fully vaccinated to work at a Takeda site or to engage with Takeda colleagues or anyone else on behalf of Takeda. US field-based employees must be fully vaccinated as a condition of employment, absent an approved religious or medical reason. US employees who work at a Takeda manufacturing facility, and those who work at a BioLife center or BioLife lab, may be subject to different guidelines. If you are contacted by a Takeda recruiter about your job application, we encourage you to seek more information on the applicable guidelines for the Business Unit/Function to which you have applied.

Empowering Our People to Shine

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In accordance with the CO Equal Pay Act, Colorado Applicants Are Not Permitted to Apply.

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EEO Statement

Takeda is proud in its commitment to creating a diverse workforce and providing equal employment opportunities to all employees and applicants for employment without regard to race, color, religion, sex, sexual orientation, gender identity, gender expression, parental status, national origin, age, disability, citizenship status, genetic information or characteristics, marital status, status as a Vietnam era veteran, special disabled veteran, or other protected veteran in accordance with applicable federal, state and local laws, and any other characteristic protected by law.

Locations

Boston, MA

Worker Type

Employee

Worker Sub-Type

Regular

Time Type

Full time