Senior Scientist I Process Development at St. Jude Children's Research Hospital in Memphis, Tennessee

Job Description:

Overview



The Therapeutic Production and Quality department is looking for a Sr. Scientist I Process Development to design and implement process development experiments with minimal supervision, both upstream and downstream unit operations. In this role you will perform small scale culture experiments, set up and run bioreactors for culture of mammalian or bacterial cells, and optimize purification methods using various chromatography techniques. Experience in mammalian and bacterial cell culture, bioreactors, protein purification, plasmid DNA purification, tangential flow filtration and various other filtration techniques is preferred. You will generate purified plasmid DNA and gene therapy vectors including Lentiviral vectors. 

Responsibilities

• Develop and maintain processes according to the requirements for drug substances and drug products as mandated by the FDA, EMA and MHRA,


• Maintain excellent electronic notebook records and generate reports that summarize all process development activities.


• Develop production batch records based on process development activities in collaboration with the Quality Assurance Department of Children's GMP, LLC. If needed, provide support in cGMP manufacturing.

Minimum Education

• Bachelor's degree in Biological Sciences, Chemical Engineering or Bioprocessing or related field required


• MS or Ph.D. preferred.

Minimum Experience



Eight (8) years of related experience with a BSFour (4) years of related experience with a MSNo related experience required with a Ph.DExperience in process development in a cGMP environment is preferred

Other Information




St. Jude is an Equal Opportunity EmployerNo Search Firms:St. Jude Children's Research Hospital does not accept unsolicited assistance from search firms for employment opportunities. Please do not call or email. All resumes submitted by search firms to any employee or other representative at St. Jude via email, the internet or in any form and/or method without a valid written search agreement in place and approved by HR will result in no fee being paid in the event the candidate is hired by St. Jude.COVID-19 vaccine:St. Jude Children’s Research Hospital has mandated the COVID-19 vaccine for all employees, excluding those with an approved medical or religious accommodation, as a condition of employment. 48633 Apply Now