Seeking a highly motivated and team-oriented Manufacturing Chemist with experience in oligonucleotide synthesis to join our Primer Manufacturing group. The candidate must have a strong understanding of purification techniques used in the manufacture of complex nucleotides, such as Ion Exchange and Hydrophobic Interaction Chromatography. The candidate should have at least one year of chemistry bench experience in synthetic processes.
Follow established processes and protocols for the synthesis of complicated organic molecules and modified oligonucleotides
Synthesize complex organic molecules and modified oligonucleotides per established protocols
HPLC purification and analysis of complex organic molecules and modified oligonucleotides
Operate in compliance with all appropriate regulatory and safety requirements
Work with cross-site and cross-functional teams in R&D, EH&S, Product Marketing, and Manufacturing Engineering
Collaborate with cross-functional teams to assess safety and quality risks and drive improvements where appropriate.
Perform safety and quality inspections through an established 6S program
At least 2 years of experience in synthetic chemistry processes, purification, analysis of organic molecules, and modified oligonucleotides
Demonstrated ability to follow established protocols in the production of complex organic molecules and modified oligonucleotides
Solid technical knowledge of synthetic organic chemistry, HPLC methods, manufacturing processes, manufacturing information systems
Excellent written and verbal communication skills required; including demonstrated experience in GDP.
Experience working in a regulated GMP manufacturing environment under ISO 13485/or 21 CFR 820
Working knowledge of SAP
Basic knowledge of the life science industry and experience in DNA analysis methods preferred
Experience in lean manufacturing and continuous improvement methodologies is preferred.
Basic understanding of equipment/instrument upkeep, calibration, and maintenance policies.
Basic understanding of manufacturing costing is preferred.
Bachelor’s degree in Biochemistry or Chemistry required
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