Senior Scientist - Antibody Discovery at AstraZeneca in Gaithersburg, Maryland

Posted in Other 4 days ago.

Job Description:

Sr Scientist - Antibody Discovery

At AstraZeneca we work together across global boundaries to make an impact and find answers to challenges. We do this with the upmost integrity even in the most difficult situations because we are committed to doing the right thing. We continuously forge partnerships that help pursue world-class medicines in new ways, combining our people's exceptional skills with those of people from all over the globe. As apart of our Protein Engineering team inGaithersburg, MD, you'll play a pivotal role in channeling our scientific capabilities to make a positive impact on changing patients' lives.

About AstraZeneca in Gaithersburg, MD

Our Gaithersburg, Maryland facility creates life-changing medicines for people around the world. This campus employs more than 3,500 experts in our field and is only a short drive from Washington, DC. This modern and vibrant scientific campus is the home of R&D and Oncology in the US. Here, we play host to some of the most cutting-edge technology and lab spaces, all designed to inspire collaboration and cross-functional science. We believe employees benefit from being challenged and inspired at work. We are dedicated to creating a culture of inclusion and collaboration.

The Gaithersburg site offers a variety of amenities to help boost productivity and help keep our employees happy and healthy. This includes a fitness center, employee healthcare clinic, electric vehicle charging stations, dry cleaning, full-service cafeteria and copy center. This is where you'll find newly-designed, activity-based work spaces to suit a variety of working styles while increasing collaboration between teams.

Summary of the Group

The Antibody Discovery and Protein Engineering (ADPE) department at AstraZeneca is constantly pushing the boundaries of science to deliver life-changing medicines to patients, with a passion for discovery and a pipeline to show for it. We're utilizing our expertise in protein and antibody engineering to enable novel therapeutic approaches to Oncology, Respiratory, Inflammatory, Cardiovascular and Infectious disease. We offer a unique and strong collaborative network as part of the AstraZeneca family, as together we explore new and exciting technologies.

Main Duties and Responsibilities:

As a member of the Antibody Discovery and Protein Engineering group your main responsibilities will include planning and executing experiments related to lead discovery, antibody characterization and developing protein engineering platforms for therapeutic antibody generation and optimization. She/he will work with scientists to create research plans, execute experiments, analyze and interpret data and present results to the group and the department. She/he is expected to have a strong work ethic, excellent organizational skills and keep good records. Strong team-based communication and presentation skills will be required.

  • Design and execute antibody discovery campaigns using phage display and B-cell isolation technologies
  • Evaluate novel protein therapeutics, including binding affinity, therapeutic efficacy, and mechanism of action studies
  • Contribute to the design and engineering of technology platform builds such as immune engager novel modalities, ADCs, Fc domains and protein mimetics.
  • Interpret data in the context of multidisciplinary project teams

Educational requirements:

A degree in the life sciences (ideally in the areas of cell biology, molecular biology, protein engineering or similar) with applicable experience, as follows:

  • PhD with 0-2 years of experience
  • MS with 4+ years of experience
  • BS with 8+ years of experience

Required skills:
  • Experience with antibody selection techniques using phage display; Familiarity with antibody-drug conjugates (ADCs)
  • Strong background in modern molecular biology techniques with experience in cloning, PCR and sequencing
  • Experience with antibody characterization techniques including SDS-PAGE, SPR and SEC; Experience with mode of action, PK assay development and antibody internalization
  • Experience with cytotoxicity assays, cellular screening, affinity assessments and flow cytometry
  • Experience with cell culture, recombinant protein production and purification.
  • Ability to conceive of and design experiments, develop assays, optimize protocols, and interpret experimental results, as well as to learn and embrace new technologies quickly, work independently and communicate well with the team

Desired skills:
  • Experience with yeast display and B-cell discovery platforms
  • Experience with ybridoma/B-cell technologies
  • Skilled in V-gene recovery from mammalian cells.
  • Experience with automation platforms

Why AstraZeneca?

At AstraZeneca when we see an opportunity for change, we seize it and make it happen, because any opportunity no matter how small, can be the start of something big. Delivering life-changing medicines is about being entrepreneurial - finding those moments and recognising their potential. Join us on our journey of building a new kind of organisation to reset expectations of what a bio-pharmaceutical company can be. This means we're opening new ways to work, pioneering cutting edge methods and bringing unexpected teams together. Interested? Come and join our journey.

So, what's next?

Are you already imagining yourself joining our team? Good, because we can't wait to hear from you.

Where can I find out more?

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