Director, Toxicology at Alnylam Pharmaceuticals in Cambridge, Massachusetts

Job Description:

Director, Toxicology

Overview

Alnylam is the world's leading RNA interference (RNAi) company.

Founded in 2002, Alnylam was built upon a bold vision of turning scientific possibility into reality by harnessing the power of RNAi for human health as an innovative new class of medicines. We are a growing biopharmaceutical company with two approved medicines and a robust pipeline of investigational medicines focused in four strategic therapeutic areas: genetic medicines, cardio-metabolic diseases, infectious diseases, and central nervous system (CNS) and ocular diseases, including several in late-stage development.

Headquartered in Cambridge, Mass., Alnylam employs over 1,400 people in 19 countries and is rapidly growing globally, with additional offices in Norton, Mass., Maidenhead, U.K., Zug, Switzerland, Amsterdam, Netherlands, and Tokyo, Japan. Alnylam is proud to have been recognized as one of The Boston Globe's Top Places to Work five years in a row (2015-2019), a Great Place to Work in the U.K. and Switzerland in 2020 and Science Magazine's #1 Top Employer in 2019. Please visit www.alnylam.com for more information.

Summary of Key Responsibilities

• Interface effectively and knowledgeably with related disciplines (be highly conversant)
• including pathology, DMPK, biology, clinical, regulatory, pharmacology.
• Capable of highly effective interactions with Regulatory bodies in the process of product
• defense and support of filings and approval.
• Design and execute robust strategically sound nonclinical development programs and studies
• required to support drug candidate advancement and regulatory filings.
• Lead and manage non clinical studies/programs (conducted both internally and through CRO
• partners) either directly or through subordinates across a number of programs.
• Ability to critically evaluate written scientific and regulatory documents for overall quality,
• clarity of presentation, and acceptability of scientific interpretation.
• Collaborate on design of investigative toxicology studies in support of development compounds
• or platform technology assessments.
• Interact cross functionally within the Early Development group, with project teams, as well as
• across other drug development expertise areas.
• Present key findings and influence thinking of program teams, R&D leadership, and regulatory
• authorities.
• Manage and mentor less senior toxicologists and scientists and guide the establishment of
• organizational expertise around the discipline of pharmaceutical toxicology and safety.
• Responsible for hiring, professional development, and guidance of direct reports .

• PhD in Toxicology, Pathology, or related discipline
• 10-15 years or more experience in the Pharmaceutical Industry with proven abilities and
• achievements within the Discovery Toxicology/Investigative/Regulatory Toxicology arena for
• predictive safety assessments.
• Ability to interpret and integrate complex data sets across multiple disciplines including
• pharmacology, DMPK, toxicology and pathology assessing the clinical relevance and impact.
• Proven ability to creatively seek resolutions to issues of predictive toxicology.
• Strong problem solver who is highly organized with the ability to thrive and to lead in an
• environment with rapidly changing priorities.
• Strong interpersonal skills with an ability to develop solid, long term relationships and the
• ability to influence others, and adept at working across multiple cross-functional areas.
• Ability to navigate and be successful in a fast-paced, highly-networked and program team
• driven environment