Senior Scientist at Rigel Pharmaceuticals, Inc. in South San Francisco, California

Job Description:

POSITION SUMMARY:

As a key senior member of our research group, the candidate will be responsible for driving the discovery of novel small molecule inhibitors and investigating their mechanism of action, with a focus on inflammation and autoimmunity.

ESSENTIAL DUTIES AND RESPONSIBILITIES:

• Independently design, plan, implement and analyze assays to fully characterize the effect of novel small molecule drug candidates on intracellular signaling


• Develop new assays relevant to therapeutic targets of interest and that will aide in lead candidate selection and/or broader understanding of the therapeutic potential of small molecule inhibitors; read the literature and gain a solid understanding of the biology of Rigel's preclinical targets


• Critically analyze data and provide summaries to project teams and senior management team


• Interact with senior management and other scientists and functional groups to formulate and implement strategies for Rigel's research programs


• Potential to lead a project including managing compound screening flow, communicating results to other functional areas and managing project team


• Prepare documents for regulatory filings and interactions with partners and collaborators


• Present Rigel data internally and at scientific conferences

KNOWLEDGE AND SKILL REQUIREMENTS:

• PhD degree in the field of cell signaling, immunology, biochemistry or related discipline


• 5+ years of experience in industry/drug development and/or independent research


• Must be familiar with immunological principles and/or intracellular signaling


• Demonstrated scientific creativity and ability to work independently and as part of a cross-functional team


• Demonstrated technical proficiency, ability to troubleshoot to solve problems and to deliver high quality data is required


• Proficiency in protein characterization methods (western-blot/Jess), primary cell isolation and culture, ELISA, Luminex, and Flow Cytometry is highly desirable


• Experience with imaging or immunohistochemistry would be a plus


• Excellent organizational, interpersonal and communication skills and can thrive in a highly collaborative research environment


• Highly motivated with high degree of professional integrity and strong work ethic

WORKING CONDITIONS:

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  PHYSICAL DEMANDS: While performing the duties of this job, the employee is required to stand, walk; sit; talk and hear. Specific vision abilities required by this job include close vision, distance vision, peripheral vision, depth perception and the ability to adjust focus.


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  WORK ENVIRONMENT: The noise level in the work environment is usually moderate. Some travel may be required.

Rigel Pharmaceuticals, Inc. is an equal opportunity employer, and all qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, genetic information, national origin, protected veteran status, disability status, or any other characteristic protected by the law.