Scientist I (Pharmacology, Formulation) at Exelixis, Inc. in Alameda, California

Job Description:

Company Description

Every Exelixis employee is united in an ambitious cause: to launch innovative medicines that give patients and their families hope for the future. In this pursuit, we know our employees are our most valuable asset. After operating in the challenging biotech sector for 25 years, we have a proven track record of resiliency in the face of adversity. The success of our lead product has provided a solid commercial foundation allowing us to reinvigorate our research efforts, and grow our team in areas such as Drug Discovery, Clinical Development and Commercial.

As we expand our global partnerships and further reinvest in R&D to help us discover the next breakthrough for difficult-to-treat cancers, we're seeking to add talented, dedicated employees to power our mission.

Cancer is our cause. Make it yours, too.

Position Description:

The successful and highly motivated candidate will support the in vivo pharmacology research program to perform pre-formulation work, develop formulation study, execute analytical test methods, organize the data and summarize related reports.

Position Requirements:

ESSENTIAL DUTIES AND RESPONSIBILITIES:
• Conduct preformulation assessment studies of various small molecule drug compounds
• Select suitable formulations and prepare test articles as required to support PK, PD, efficacy and toxicology studies
• Evaluate and characterize the physical and chemical behavior of drug product formulations, including stability tests and force degradation studies
• Develop or modify, as required, any analytical methodology required to understand and characterize formulations or drug candidates
• Keep accurate laboratory data records and summarize data as needed
• Adhere to good health and safety practices and compliance with applicable EH&S rules and participate in mandatory safety training programs

EDUCATION/EXPERIENCE/KNOWLEDGE & SKILLS:
Education:
• Bachelor's degree in a related chemistry, pharmaceutical sciences, biochemistry, biology discipline and two to four years of related experience; or
• Master's degree in a related chemistry, pharmaceutical sciences, biochemistry, biology discipline and zero to two years of related experience; or
• Equivalent combination of education and experience.

Experience:
• Two or more years of experience in pharmaceutical development, preformulation, formulation and/or analytical development preferred.
• Experience with preparing various types of dosages such as oral, parenteral (injectable solution or suspension) and other formulations for drug delivery systems is required.
• Hands-on experience with analytical instruments including UPLC/HPLC, DSC, TGA, XRPD, particle sizing measurement, optical microscopy, etc.
• Excellent data analysis skills and experience with a variety of scientific/statistical software applications is preferred

Knowledge/Skills:
• Proficiency with computers including MS Word, MS PowerPoint, and MS Excel is required
• Demonstrated problem solving skills and written/verbal communication skills
• Deep knowledge of solid-state characterization, liquid formulation development and drug delivery
• In-depth understanding of pre-formulation, formulation, biopharmaceutics principles required to get a drug from discovery through clinical development is desirable
• Works effectively independently and capable of multi-tasking and prioritizing assignments
• Excellent collaborative, verbal and written communication skills, problem solving, critical thinking, and organization skills
• Detail oriented, can multi-task and work on multiple projects concurrently. Ability to work in a fast-paced organization
• Advanced knowledge of MS Office, PDF, GraphPad prism, Chemstation and ELN notebook is required

WORKING CONDITIONS:
• Environment: primarily working in laboratories or in office
• Travel not required
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DISCLAIMER

The preceding job description has been designed to indicate the general nature and level of work performed by employees within this classification. It is not designed to contain or be interpreted as a comprehensive inventory of all duties, responsibilities and qualifications required of employees assigned to the job.

We are an Equal Opportunity Employer and do not discriminate against any employee or applicant for employment because of race, color, sex, age, national origin, religion, sexual orientation, gender identity, status as a veteran, and basis of disability or any other federal, state or local protected class.