Principal Scientist, Biocontinuum at MilliporeSigma in Bedford, Massachusetts

Job Description:

A career with MilliporeSigma is an ongoing journey of discovery: our 60,300 people are shaping how the world lives, works and plays through next generation advancements in Healthcare, Life Science and Electronics. For more than 350 years and across the world we have passionately pursued our curiosity to find novel and vibrant ways of enhancing the lives of others. MilliporeSigma is a business of Merck KGaA, Darmstadt, Germany.


Your Role:



We are seeking a highly motivated senior scientist or engineer to join the company as a Principal Process Analytical Technology (PAT) Scientist! A meaningful and business critical role within the BioContinuum™ Platform Applications & Innovation team. We are working at bench-scale, leading the evolution and convergence of process, analytical, and digital technologies to pioneer a facility of the future for continuous biomanufacturing.

Key responsibilities include:

• Driving the development of at-line, in-line, and on-line PAT methods for intensified bioprocessing through technology scouting and execution of lab-based evaluations within connected production and purification trains.


• Collaborating with process and data scientists/engineers to identify and display real-time or near-real time performance indicators, develop mechanistic and hybrid predictive models, and develop sophisticated process control strategies utilizing next generation sensors.


• Crafting our PAT strategy in intensified and continuous biomanufacturing by leveraging your industrial experience and understanding of manufacturing pain points and bottlenecks to propose new project concepts, to align objectives with key stakeholders, and to execute on project plans.


• Engagement with customers, industry consortia, and internal colleagues to ensure evolving requirements for continuous manufacturing are designed into the capabilities of our product pipeline and evaluated under real-world conditions to enable successful implementation of our solutions.


• Disseminating key results by delivering internal and external thought leadership activities.

Location: Bedford, MA


Who you are




Minimum Qualifications:

• BS Degree in Chemical Engineering, Analytical Chemistry, Biochemistry, Biochemical Engineering, or related discipline with minimum 12 years of direct experience; MS with 10 years or PhD with 7 years


• Hands-on experience in analytical techniques for protein quality and purity, particularly for CHO cell-based processes and monoclonal antibodies


• Proficiency with spectroscopy (i.e. Raman, NIR, MIR, UV), chemometrics, statistics, multivariate data analysis, and modeling of complex spectroscopy data.


• Ability to tackle problems creatively and contribute to innovation in product and process development


• Experience managing numerous projects simultaneously to meet deliverables and timelines


• Excellent verbal and written communication skills; ability to present at internal and external meetings and produce publication-quality documentation


• Proven track record as a committed team member having worked on multi-disciplinary teams in a matrix environment

Preferred Qualifications:

• Background in approaches and implementation of PAT for real-time monitoring and control of key process parameters and quality attributes is desired


• Experience with lab-based automation and data processing software, including feed-forward and feed-back control loop implementation is a plus


• Solid understanding of pharmaceutical/biotechnology regulatory and quality issues including GMP regulations and QbD principles

What we offer: We are curious minds that come from a broad range of backgrounds, perspectives, and life experiences.
We celebrate all dimensions of diversity. We believe that it drives excellence, innovation, and human progress. We care about our customers, patients, and our rich mix of people. This diversity strengthens our ability to lead in science and technology.
We are committed to creating access and opportunities for all and empower you to fulfil your ambitions. Our diverse businesses offer various career moves to seek new horizons.
Join us in building a culture of inclusion and belonging that impacts millions and empowers everyone to bring their curiosity to life!



Curious? Chat with one of our curious minds on our interactive Q&A platform and catch a glimpse of our people, values, and culture. You can also apply and find more information at https://jobs.vibrantm.com
If you would like to know more about what diversity, equity, and inclusion means to us, please visit https://www.emdgroup.com/en/company/press-positions.html


If you are a resident of NYC, Connecticut or Colorado, you are eligible to receive additional information about the compensation and benefits, which we will provide upon request. You may contact 855 444 5678 from 8:00am to 5:30pm ET Monday through Friday, for assistance.


The Company is an Equal Employment Opportunity employer. No employee or applicant for employment will be discriminated against on the basis of race, color, religion, age, sex, sexual orientation, national origin, ancestry, disability, military or veteran status, genetic information, gender identity, transgender status, marital status, or any other classification protected by applicable federal, state, or local law. This policy of Equal Employment Opportunity applies to all policies and programs relating to recruitment and hiring, promotion, compensation, benefits, discipline, termination, and all other terms and conditions of employment. Any applicant or employee who believes they have been discriminated against by the Company or anyone acting on behalf of the Company must report any concerns to their Human Resources Business Partner, Legal, or Compliance immediately. The Company will not retaliate against any individual because they made a good faith report of discrimination.


As an employee of the Company, you will be required to comply with all of the Company's COVID-19 safety protocols and policies. The organization has currently suspended enforcement of its COVID-19 Vaccination Policy, but that policy may be reinstated by the Company in its discretion.


Job Requisition ID: 246205


Location: Bedford


Career Level: E - Professional (10+ years)


Working time model: full-time Apply Now