Develop LC-MS/MS methods and analyze in vitro and in vivo samples to support ADME, pharmacokinetic, and toxicokinetic studies.
Perform data analysis, provide reports of experimental results, and upload data to the electronic system and electronic notebook.
Conduct in vitro metabolic stability studies in bio-matrices, including hepatocytes, microsomes, blood, and plasma.
Perform in vitro ADME/DMPK assays, such as CYP inhibition and metabolic profiling.
Assist in operating, maintaining, and troubleshooting LC-MS/MS instruments.
Requirements and Qualifications:
A bachelor's or master's degree in Pharmaceutical Sciences or a related scientific discipline, with 3+ years of industry experience.
Hands-on experience in operating and maintaining an LC-MS/MS systems
Hands-on experience in LC-MS/MS method development and bioanalytical analysis
Knowledge of biological sample preparation and extraction techniques for downstream LC-MS/MS analysis
Hands-on experience in HPLC/UPLC method development
Able to conduct multiple laboratory and project tasks efficiently
Able to work in a team-oriented environment with flexibility
Highly organized, detail-oriented, excellent record-keeping skills, and adapt to a dynamic and fast-paced environment
Previous hands-on experience in SCIEX QTRAP or Thermo Q Exactive mass spectrometers is preferred.
Working experience with DMPK lab is a plus.
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Desired Skills and Experience LC-MS/MS, bioanalytical analysis, HPLC/UPLC, SCIEX QTRAP, Thermo Q, DMPK