Senior Scientist, Assay Development & High-Throughput Screening at Pfizer in Cambridge, Massachusetts

Job Description:

Senior Scientist, Assay Development and High-Throughput Screening (HTS)

 

Pfizer's BioMedicine Design (BMD) Assay Development group is seeking a highly motivated scientist with experience in liquid-handling automation to establish binding and functional assays to support hit-to-lead discovery of and antibody and mRNA therapeutics. The candidate will play a critical role in the design and execution of biochemical and of cell-based functional assay and high-throughput screening to support the BioMedicine Design portfolio. The candidate will be responsible for the design and execution of experiments using a variety of detection technologies including HTRF, ELISA/DELFIA, FACS, and cell-based functional assays focused on signaling, proliferation, or cytotoxicity. In addition, the candidate will analyze data, present results at internal meetings, and closely collaborate with project team members to develop strategies and identify lead molecules. We are looking for a creative, solution-oriented individual who enjoys the opportunity to explore new methods.

 

What You Will Achieve

 

• Develop assays to identify and characterize antibody and mRNA hits to support programs across multiple therapeutic areas. Biochemical assay formats include binding, competition and enzymatic cleavage assays. Cell based assays include binding, competition, cell signaling (NanoBiT, Ca2+ flux, cAMP, phospho-protein) and reporter gene assays using a variety of cell lines and primary immune cells.
• Execute high-throughput screens using integrated automation platforms, including rapid data analysis and reporting of results.
• Collaborate with project teams to establish screening strategies, interpret results, and make decisions to drive programs forward.
• Write protocols, maintain ELN, and regularly review literature to m aintain knowledge of scientific trends and new technologies.

 

QUALIFICATIONS

 

Must Have

 

• Bachelor's degree with 9+ years of experience, or master's degree with 6+ years of experience in molecular biology, biochemistry, cell biology or a related discipline, along with a comprehensive understanding of biologics drug discovery workflows or PhD Degree
• Demonstrated expertise in assay development and troubleshooting with methods such as HTRF, ELISA/DELFIA, FACS, and cell-based functional assays focused on signaling, proliferation, or cytotoxicity.
• At least 6 years of industry experience in high-throughput screening and data analysis.
• At least 6 years of experience with using laboratory automation, including writing and troubleshooting protocols.
• Track record of strong problem solving and organizational skills, attention to detail, and ability to multi-task.
• Strong written and oral communication skills.

 

Nice to Have

 

• Experience with Tecan and Beckman liquid handling platforms and Momentum scheduling software.
• Experience with high content imaging and multiplex assay formats.
• Experience with primary immune cells and multicolor FACS.
• Experience with GeneData or other LIMs platforms, and with writing scripts to automate data processing.
• Experience mentoring junior lab members.

 

Other Job Details

 

Work Location: On Premise

 

The annual base salary for this position ranges from $88,300.00 to $147,100.00. In addition, this position is eligible for participation in Pfizer's Global Performance Plan with a bonus target of 12.5% of the base salary and eligibility to participate in our share based long term incentive program. We offer comprehensive and generous benefits and programs to help our colleagues lead healthy lives and to support each of life's moments. Benefits offered include a 401(k) plan with Pfizer Matching Contributions and an additional Pfizer Retirement Savings Contribution, paid vacation, holiday and personal days, paid caregiver/parental and medical leave, and health benefits to include medical, prescription drug, dental and vision coverage. Learn more at Pfizer Candidate Site - U.S. Benefits | (uscandidates.mypfizerbenefits.com). Pfizer compensation structures and benefit packages are aligned based on the location of hire. The United States salary range provided does not apply to Tampa, FL or any location outside of the United States.

 

Relocation assistance may be available based on business needs and/or eligibility.

 

Sunshine Act

 

Pfizer reports payments and other transfers of value to health care providers as required by federal and state transparency laws and implementing regulations. These laws and regulations require Pfizer to provide government agencies with information such as a health care provider's name, address and the type of payments or other value received, generally for public disclosure. Subject to further legal review and statutory or regulatory clarification, which Pfizer intends to pursue, reimbursement of recruiting expenses for licensed physicians may constitute a reportable transfer of value under the federal transparency law commonly known as the Sunshine Act. Therefore, if you are a licensed physician who incurs recruiting expenses as a result of interviewing with Pfizer that we pay or reimburse, your name, address and the amount of payments made currently will be reported to the government. If you have questions regarding this matter, please do not hesitate to contact your Talent Acquisition representative.

 

EEO & Employment Eligibility

 

Pfizer is committed to equal opportunity in the terms and conditions of employment for all employees and job applicants without regard to race, color, religion, sex, sexual orientation, age, gender identity or gender expression, national origin, disability or veteran status. Pfizer also complies with all applicable national, state and local laws governing nondiscrimination in employment as well as work authorization and employment eligibility verification requirements of the Immigration and Nationality Act and IRCA. Pfizer is an E-Verify employer. This position requires permanent work authorization in the United States.

 

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